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Animal studies test doses of 100 to 500 mg/kg

Upon physical examination, acute TFCC injuries present with ulnar-sided wrist swelling

Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)